Reproduction

In this unit, students continue their exploration of the cell with a focus on the phenomenon of DNA. Students use models to compare and contrast asexual and sexual reproduction and to investigate how traits are passed down from parents to offspring. This page is a high-level extract of this lesson.

Science Background for Teachers:

Science background provides teachers with more in-depth information on the phenomena students explore in this unit. Below is an excerpt from this section on reproduction.

Mitosis

After DNA replicates, there is an exact copy of each chromosome. The identical chromosomes are called sister chromatids, and they are linked together by the centromere. DNA replication produces an exact copy of each chromosome. The two identical chromosomes are called sister chromatids.

Once a cell has replicated its DNA and there are sister chromatids, the cell gets ready to divide so it can pass along its genetic information to its offspring. There are several reasons why cells divide. One important reason is growth. The more cells an organism has, the larger that organism is. For example, humans start off as a single cell. By the time they are adults, they have trillions of cells. Blue whales have roughly 1,000 times more cells than humans.

Cell division also allows cells to repair damaged cells or replace dead cells. For example, human skin cells constantly divide so they can replace damaged or dead skin cells. Muscle cells also divide frequently to replace cells damaged by exercise or injury.

Cell division allows cells to reproduce. Reproduction is the ability of a mature organism to have offspring. Almost all cell division happens through a process called mitosis. Mitosis is a form of cell division that takes place in eukaryotic cells and results in two daughter cells with the same number of chromosomes as the parent cell.

Steps of Mitosis

There are four phases as a parent cell separates its chromosomes into two daughter cells.

Phase 1: Prophase— When the cell is ready to divide, DNA is wrapped even more tightly, and the chromosomes become visible. Each chromosome consists of the two sister chromatids formed during replication. The nuclear membrane breaks down and the chromosomes are freed from the nucleus. Small fibers called spindle fibers begin to grow from the centrosomes on opposite sides of the cell and attach to each sister chromatid at its centromere.

Phase 2: Metaphase— During metaphase, the chromosome pairs line up in the middle of the cell end- to-end. This formation ensures that each daughter cell will receive one copy of each chromosome.

Phase 3: Anaphase—Separation begins. The sister chromatids separate and the spindle fibers pull one complete set of an organism’s chromosomes to each end of the cell. For humans, 46 chromosomes move to each end of the cell. Each side receives the same number and kind of chromosomes as the parent cell.

Phase 4: Telophase—During telophase, the chromosomes reach opposite ends of the cell. Nuclear envelopes reassemble and enclose each cell’s set of chromosomes in a nucleus. The chromosomes become indistinct chromatin.

After telophase, most cells undergo a process called cytokinesis in which the rest of the cell splits apart, resulting in two separate daughter cells.

Benefits & Drawbacks

The result of mitosis is two daughter cells that are exact replicas of each other and the parent cell. In a multicellular eukaryotic organism, mitosis is how the organism grows. In a single-celled eukaryotic organism, mitosis is how the organism reproduces because the daughter cells are new organisms.

This is a form of asexual reproduction because it requires only one parent. Asexual reproduction is the most ancient method for passing on genetic material. The passing on of traits from parents to offspring is called heredity. Most unicellular organisms reproduce asexually, although a few multicellular organisms also reproduce this way. In prokaryotic cells, which do not have a nucleus to hold their genetic material, cell division is similar to mitosis because the cell replicates its DNA and the two copies split into two halves of a dividing cell. The result is two daughter cells that have the same genetic material as the parent cell.

From a reproductive standpoint, there are certain advantages to this process. Organisms do not need to expend time or energy searching for a mate, and all of an organism’s genes are passed on to its children. It also can occur rapidly; for example, bacteria can divide several times per hour.

However, there is very little genetic diversity in asexual reproduction. Because one parent passes along an exact genetic replica, the same genes are passed down from generation to generation. If one individual cannot overcome a type of disease or a rapid climate change, then all other offspring from the same parent are equally vulnerable.

Meiosis

Nature’s answer to this problem of lack of diversity was sexual reproduction, which creates offspring with the combined genetic information of a male and a female. The combination of genes ensures that each offspring has a different set of traits.

Humans and other complex organisms reproduce sexually through fertilization—the fusion of two gametes (cells that only contain half of an organism’s chromosomes). When a gamete from a male combines with a gamete from a female, the two joined gametes create a new individual that has a complete set of chromosomes.

Gametes are formed during a special kind of cell division called meiosis, which only happens when cells in sexually reproducing organisms prepare for reproduction. In meiosis, the cell divides twice, resulting in four daughter cells, each with half the chromosome number of the parent cell.

Just as in mitosis, the chromosomes must duplicate before meiosis can take place. The same four phases of mitosis— prophase, metaphase, anaphase, and telophase—occur during both meiosis I and meiosis II. However, there are a few key differences at various steps in the process.

During prophase I, the homologous chromosomes pair up. Because each homologous pair has two sister chromatids, there are four chromatids close together. As they line up close together, the non-sister chromatids exchange genetic information. This is called crossing-over, and it occurs at random places along the chromosomes. This is an important difference from mitosis because it results in chromosomes that have different genetic information.

During metaphase I, the chromosome pairs line up at the equator side by side. The chromosome pairs separate and they are pulled toward different sides of the cell. The cell divides. There are now two new cells, and each cell has one chromosome from each chromosome pair. The chromosomes are duplicated, so each still has two sister chromatids. The two daughter cells get ready to divide again.

In meiosis II, the cells go through the same phases as in mitosis. Because there was no DNA replication, however, there are not two sets of chromosomes. In metaphase II, the chromosomes in each of the two daughter cells line up in the middle of the cell end to end. The sister chromatids separate, and the nuclei of each daughter cell divides again.

By the end of meiosis, there are four daughter cells. These daughter cells are called gametes because they have just half of the chromosomes as the parent cell, and are genetically different from the parent cell and from each other.

Supports Grade 8

Science Lesson: Investigating Reproduction

In this lesson, students focus on how genetic information is passed down from parents to offspring when cells divide. They model the two forms of cell division (mitosis and meiosis), and use their models to support an argument for how asexual reproduction phenomena is different from sexual reproduction phenomena.

Science Big Ideas

  • Almost all of the cells in a multicellular organism have the same DNA because of DNA replication and cell division.
  • As organisms grow, their cells aren’t growing bigger and bigger. Instead, they grow because their cells are duplicating. They do this through cell division. Cell division refers to the splitting of a single cell into daughter cells, each with DNA from its parent cell.
  • Right before a cell gets ready to divide, its DNA condenses into threadlike structures called chromosomes. Each chromosome is made up of a single DNA molecule, and it holds hundreds or thousands of genes on it.
  • The cell has to undergo some structural changes in order for mitosis to take place.

Sample Unit CTA-2
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Science Essential Questions

  • Why does DNA need to replicate before the cell divides?
  • How is DNA replication different from transcription, which happens during protein synthesis?
  • What is the relationship between the replication of DNA and heredity?
  • Why do humans have chromosome pairs?
  • What happens to the cell’s chromosomes after mitosis?
  • Why does the nucleus have to change during mitosis?
  • How does the cell ensure that the daughter cells will receive one copy of each chromosome?
  • What causes the sister chromatids to separate?
  • What has to happen once each side of the cell has the same number and kind of chromosomes as the parent cell?
  • When does mitosis happen in the human body?

Common Science Misconceptions

Misconception: In sexually reproducing organisms, one parent contributes genes for some characteristics while the other parent contributes genes for other characteristics.

Fact: Both parents contribute genes for every characteristic in sexually reproducing organisms.

Science Vocabulary

Asexual reproduction : reproduction that requires only one parent (e.g., binary fission, budding, and fragmentation)

Cell division : the splitting of a single cell into daughter cells, each with DNA from its parent cell

Chromosome : a threadlike structure of DNA and protein; found in the nucleus of eukaryotic cells; a discrete package of genetic material

Daughter cell : a cell formed by the division of a parent cell

Heredity : the passing on of traits from parents to offspring

Meiosis : a form of cell division that results in four daughter cells, each with half the chromosome number of the parent cell

Mitosis : a form of cell division that results in two daughter cells with the same number and kind of chromosomes as the parent cell

Replicate : to make a copy of

Reproduction : the ability of a mature organism to have offspring

Sexual reproduction : the creation of a new individual from combined genetic information of two parents of different sexes

Lexile(R) Certified Non-Fiction Science Reading (Excerpt)

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The Journey of a Sea Turtle

Every year, the leatherback sea turtle travels up to 16,093 kilometers (10,000 miles) and crosses the entire Pacific Ocean in search of jellyfish, which is its primary diet. It then returns to tropical waters to nest and breed. The leatherback is the largest of all sea turtles. An adult can weigh between 227 and 907 kilograms (500 and 2000 pounds).

The male sea turtle never leaves the ocean, while the female comes on land to lay her eggs in nests on sandy beaches. Once she lays her eggs, the female sea turtle leaves them and returns to the ocean. The temperature of the nest determines whether the eggs will become male or female turtles. If temperatures are between 28-29 degrees Celsius (83- 85 degrees Fahrenheit), the eggs will develop into a mix of male and female turtles. Temperatures warmer than this produce females, while temperatures lower than this produce males. Once the baby turtles hatch, they are on their own to make their way to the ocean. If they survive the journey, they will grow, becoming larger as they turn into adults.

 

Cell Division and Growth

As baby sea turtles grow and turn into adults, their cells aren’t growing bigger and bigger. Instead, they grow because their cells are duplicating. They do this through cell division. Cell division refers to the splitting of a single cell into daughter cells, each with DNA from its parent cell.

This is true for all multicellular organisms. For example, you started out as a single cell. That one cell divided, and then those daughter cells all divided, and then the daughter cells of those daughter cells divided. This continues until you reach adulthood, at which point your body will be made up of trillions of cells.

Before a cell can divide, it grows until it is double in size. This growth is important because the cell also has to replicate its DNA. To replicate means to make a copy of. Remember how in protein synthesis, part of the DNA double helix unzips and separates so that a template can be used for making an mRNA molecule?

The entire DNA molecule can also unzip. This is because each strand of the double helix runs in opposite directions. At a certain point, the twisted, tightly packed double helix unwinds and separates its two strands, unzipping down the middle. Each strand serves as a template for a new strand of DNA molecules.

The two new strands are both exact copies of the original DNA molecule because A nucleotides are added wherever there are Ts, and Cs where there are Gs.

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pattern

Chromosomes

DNA replicates itself right before a cell gets ready to divide. Because of DNA replication, a copy of an organism’s DNA gets passed along to the daughter cells. This is how all of your cells contain the same DNA.

Right before a cell gets ready to divide, its DNA condenses into threadlike structures called chromosomes. Each chromosome is made up of a single DNA molecule, and it holds hundreds or thousands of genes on it. The genes are located on the chromosomes in a very specific way. Because of this, if scientists know where one gene is located, they can find it on anyone’s chromosomes.

Different kinds of organisms have different numbers and shapes of chromosomes. For example, prokaryotic cells don’t have a nucleus, so their DNA is spread throughout the entire cell. Most bacteria have one or two circular chromosomes. Plants and animals have linear chromosomes that are arranged in pairs. Fruit flies have four pairs of chromosomes, while lobsters have 50 pairs of chromosomes.

In humans, there are 23 pairs of chromosomes found in the nucleus of each of your cells (except for red blood cells, which don’t have a nucleus). Chromosomes are in pairs because one chromosome is inherited from each parent. The first 22 chromosome pairs are the autosomes, which are chromosomes that everyone has. They are numbered according to size. The gender-specific sex chromosomes are the final chromosome pair. Biological females have an XX combination, and biological males have an XY combination.

Both chromosomes in the chromosome pair contain genes that code for the same proteins. These are called alleles. An allele is a form of the same gene that has small differences in the sequence of DNA bases. For example, one allele might have the instructions for proteins that would result in blue eyes, while another allele might have the instructions for proteins that would result in brown eyes. Each parent contributes one allele.

After DNA replicates, there are two of each chromosome. The identical chromosomes are called sister chromatids, and they are linked together by the centromere. Once a cell has replicated its DNA, it gets ready to divide so it can pass along its genetic information to its offspring.

There are several reasons why cells divide. One important reason is growth. The more cells an organism has, the larger that organism is. Cell division also allows cells to repair damaged cells or replace dead cells. For example, human skin cells constantly divide so they can replace damaged or dead skin cells. Muscle cells also divide frequently to replace cells damaged by exercise or injury. Finally, cell division allows cells to reproduce. Reproduction is the ability of a mature organism to have offspring.

 

Hands-on Science Activity

For the main activity of this lesson, students develop and use models to show how asexual reproduction results in offspring with identical genetic information, and how parent cells in sexually reproducing organisms use the process of meiosis to produce four daughter cells that are genetically different.

Science Assessments

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Science Standards

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Standards citation: NGSS Lead States. 2013. Next Generation Science Standards: For States, By States. Washington, DC: The National Academies Press. Neither WestEd nor the lead states and partners that developed the Next Generation Science Standards were involved in the production of this product, and do not endorse it.